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Stimulation of Ovulation

Stimulation of ovulation is usually performed with the help of several medications which help a woman to bring to the norm her menstrual cycle and as a result reach ovulation and pregnancy. There are two different widespread methods of ovarian stimulation:

  • The first is used for women who are not able to ovulate spontaneously. In such cases, the aim stimulation of release of one egg a month. This is generally done by prescribing fertility pills. If this turned to be ineffective, then injections with a small dose of gonadotropins may be prescribed.

  • In the second situation, is when the woman is ovulating spontaneously but has unexplained infertility. In such a case, the aim of ovulation induction is to stimulate the production of several large follicles, and as a result several eggs will be released. This is usually achieved with the help of injections of gonadotropins. This treatment may be accompanied by intra uterine insemination aiming  to bring the sperm closer to the egg.

Medications for Ovarian Stimulation

All women who use the above mentioned methods of ovarian stimulation are monitored with vaginal ultrasound scans.  That gives an opportunity to observe the response of the follicles in the ovary. When the leading follicle reaches necessary diameter, the egg is considered mature and ready for ovulation. You may need several scans during one treatment course. The most widespread drugs used for ovarian stimulation are:

  • Clomiphene Citrate. This drug is often used for ovulation stimulation in women who have infrequent or absent ovulation;

  • Gonadotropins. Gonadotropins are fertility drugs that contain FSH or LH either alone or in combination;

  • Human Chorionic Gonadotropins (hCG). Produced in pregnant women by the placenta and extracted from the urine, hCG is similar in chemical structure and function to LH.

  • Pregnyl or FSH injections.

If you are ready to undergo medical treatment, your doctor will prescribe a precisely controlled dose of FSH or other hormones. Your doctor will carefully monitor the effect of these hormones on your organism. Normally doctors may check a woman’s estrogen level after 3 or 4 days of stimulation. If there does not seem enough response, the dose of FSH can be increased, and in opposite, if the response has been too much, then the FSH dose can be reduced.


Statistics shows that approximately 25% of infertile women have some problems with ovulation. These include the inability to produce fully matured eggs or failure to release an egg. Fertility specialists use a group of drugs, often called “fertility drugs,” to correct ovulatory problems and increase a woman’s chance for pregnancy. Fertility drugs may be used to correct other fertility problems such as improving the lining of the uterus (endometrium) in addition to inducing ovulation.